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female il 12β ko  (Jackson Laboratory)

 
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    Structured Review

    Jackson Laboratory female il 12β ko
    (A) Western blots and quantification of LV <t>IL-12β</t> expression in WT sham and WT TAC mice. (B) Survival curves of WT TAC and IL-12β KO TAC mice of both sexes (log-rank test). (C) Representative M-mode echocardiographic images of WT and IL-12β KO male mice: pre-TAC, 2 weeks, 4 weeks, and 6 weeks after TAC, and Quantified data of echocardiographic measurements of LVEF, LVFS, LVESD, and LVEDD of both sexes. (D, E) The ratio of LV weight, left atrial (LA) weight, lung weight, RV weight, right atrial (RA) weight, and total heart weight to tibial length (TL) of the indicated groups. (F) Representative LV WGA staining images and quantified data of cardiomyocyte cross-sectional areas. *p<0.05; # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 7 to 22 per group; LVEF, LV ejection fraction; LVFS, LV fractional shortening; LVESD, LV end-systolic diameter; LVEDD, LV end-diastolic diameter.
    Female Il 12β Ko, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/female+il+12%CE%B2+ko/12%CE%B2+female+il+knockout/bio_rxiv__2025__09__05__674485-30-2-5
    Average 86 stars, based on 1 article reviews
    female il 12β ko - by Bioz Stars, 2026-09
    86/100 stars

    Images

    1) Product Images from "Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development"

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development

    Journal: bioRxiv

    doi: 10.1101/2025.09.05.674485

    (A) Western blots and quantification of LV IL-12β expression in WT sham and WT TAC mice. (B) Survival curves of WT TAC and IL-12β KO TAC mice of both sexes (log-rank test). (C) Representative M-mode echocardiographic images of WT and IL-12β KO male mice: pre-TAC, 2 weeks, 4 weeks, and 6 weeks after TAC, and Quantified data of echocardiographic measurements of LVEF, LVFS, LVESD, and LVEDD of both sexes. (D, E) The ratio of LV weight, left atrial (LA) weight, lung weight, RV weight, right atrial (RA) weight, and total heart weight to tibial length (TL) of the indicated groups. (F) Representative LV WGA staining images and quantified data of cardiomyocyte cross-sectional areas. *p<0.05; # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 7 to 22 per group; LVEF, LV ejection fraction; LVFS, LV fractional shortening; LVESD, LV end-systolic diameter; LVEDD, LV end-diastolic diameter.
    Figure Legend Snippet: (A) Western blots and quantification of LV IL-12β expression in WT sham and WT TAC mice. (B) Survival curves of WT TAC and IL-12β KO TAC mice of both sexes (log-rank test). (C) Representative M-mode echocardiographic images of WT and IL-12β KO male mice: pre-TAC, 2 weeks, 4 weeks, and 6 weeks after TAC, and Quantified data of echocardiographic measurements of LVEF, LVFS, LVESD, and LVEDD of both sexes. (D, E) The ratio of LV weight, left atrial (LA) weight, lung weight, RV weight, right atrial (RA) weight, and total heart weight to tibial length (TL) of the indicated groups. (F) Representative LV WGA staining images and quantified data of cardiomyocyte cross-sectional areas. *p<0.05; # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 7 to 22 per group; LVEF, LV ejection fraction; LVFS, LV fractional shortening; LVESD, LV end-systolic diameter; LVEDD, LV end-diastolic diameter.

    Techniques Used: Western Blot, Expressing, Staining

    (A) Principal component analysis of WT and IL-12β KO mice, under sham or TAC conditions. (B) Venn diagram showing differentially expressed genes (DEGs) of WT and IL-12β KO mice under sham or TAC conditions, as well as the shared and uniquely changed genes. (C) DEGs cluster heatmap in WT mice compared to IL-12β KO mice, under sham or TAC conditions. (D) Volcano plots showing upregulated and downregulated genes among the groups. (E) Gene ontology (GO) biological process enrichment bubble chart in WT TAC mice compared to IL-12β KO TAC. (F) GO cellular component enrichment histogram shows the enriched cellular components between KO and WT mice after TAC. n = 2/group for sham and n=3/group for TAC.
    Figure Legend Snippet: (A) Principal component analysis of WT and IL-12β KO mice, under sham or TAC conditions. (B) Venn diagram showing differentially expressed genes (DEGs) of WT and IL-12β KO mice under sham or TAC conditions, as well as the shared and uniquely changed genes. (C) DEGs cluster heatmap in WT mice compared to IL-12β KO mice, under sham or TAC conditions. (D) Volcano plots showing upregulated and downregulated genes among the groups. (E) Gene ontology (GO) biological process enrichment bubble chart in WT TAC mice compared to IL-12β KO TAC. (F) GO cellular component enrichment histogram shows the enriched cellular components between KO and WT mice after TAC. n = 2/group for sham and n=3/group for TAC.

    Techniques Used:

    (A) The top 20 upregulated and downregulated pathways between KO and WT mice after TAC, identified by GSEA with ReactomeGSA. (B) Representative GESA plots of collagen formation and extracellular matrix organization. (C, D) Representative images and quantified data of LV interstitial and perivascular fibrosis performed by Sirius Red/Fast Green staining in male and female mice. # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 4-5 per group.
    Figure Legend Snippet: (A) The top 20 upregulated and downregulated pathways between KO and WT mice after TAC, identified by GSEA with ReactomeGSA. (B) Representative GESA plots of collagen formation and extracellular matrix organization. (C, D) Representative images and quantified data of LV interstitial and perivascular fibrosis performed by Sirius Red/Fast Green staining in male and female mice. # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 4-5 per group.

    Techniques Used: Staining

    (A) The top 20 upregulated and downregulated pathways between KO and WT mice after TAC identified by GSEA with KEGG pathway analysis. (B) Heatmap shows the top LV immune and/or inflammation-related genes in KO and WT mice after TAC. (C, D) Representative LV CD45 + immuno-staining images and quantified data of LV CD45 + of the indicated groups. (E) Percentage distribution of major immune cell subsets within LV CD45 + cells of the indicated groups determined by flow cytometry. # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 4-5 per group.
    Figure Legend Snippet: (A) The top 20 upregulated and downregulated pathways between KO and WT mice after TAC identified by GSEA with KEGG pathway analysis. (B) Heatmap shows the top LV immune and/or inflammation-related genes in KO and WT mice after TAC. (C, D) Representative LV CD45 + immuno-staining images and quantified data of LV CD45 + of the indicated groups. (E) Percentage distribution of major immune cell subsets within LV CD45 + cells of the indicated groups determined by flow cytometry. # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 4-5 per group.

    Techniques Used: Immunostaining, Flow Cytometry

    Related Articles

    Western Blot:

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development
    Article Snippet: Male and female IL-12β KO (Jackson Lab, Strain #002693) and wild-type (WT) C57BL/6J (Jackson Lab, Strain #000664) mice were used for sham or TAC surgery, a commonly used surgical procedure to mimic clinical conditions such as hypertension or aortic stenosis.

    Expressing:

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development
    Article Snippet: Male and female IL-12β KO (Jackson Lab, Strain #002693) and wild-type (WT) C57BL/6J (Jackson Lab, Strain #000664) mice were used for sham or TAC surgery, a commonly used surgical procedure to mimic clinical conditions such as hypertension or aortic stenosis.

    Staining:

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development
    Article Snippet: Male and female IL-12β KO (Jackson Lab, Strain #002693) and wild-type (WT) C57BL/6J (Jackson Lab, Strain #000664) mice were used for sham or TAC surgery, a commonly used surgical procedure to mimic clinical conditions such as hypertension or aortic stenosis.

    Immunostaining:

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development
    Article Snippet: Male and female IL-12β KO (Jackson Lab, Strain #002693) and wild-type (WT) C57BL/6J (Jackson Lab, Strain #000664) mice were used for sham or TAC surgery, a commonly used surgical procedure to mimic clinical conditions such as hypertension or aortic stenosis.

    Flow Cytometry:

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development
    Article Snippet: Male and female IL-12β KO (Jackson Lab, Strain #002693) and wild-type (WT) C57BL/6J (Jackson Lab, Strain #000664) mice were used for sham or TAC surgery, a commonly used surgical procedure to mimic clinical conditions such as hypertension or aortic stenosis.



    Similar Products

    female il 12β ko  (Jackson Laboratory)
    86
    Jackson Laboratory female il 12β ko
    (A) Western blots and quantification of LV <t>IL-12β</t> expression in WT sham and WT TAC mice. (B) Survival curves of WT TAC and IL-12β KO TAC mice of both sexes (log-rank test). (C) Representative M-mode echocardiographic images of WT and IL-12β KO male mice: pre-TAC, 2 weeks, 4 weeks, and 6 weeks after TAC, and Quantified data of echocardiographic measurements of LVEF, LVFS, LVESD, and LVEDD of both sexes. (D, E) The ratio of LV weight, left atrial (LA) weight, lung weight, RV weight, right atrial (RA) weight, and total heart weight to tibial length (TL) of the indicated groups. (F) Representative LV WGA staining images and quantified data of cardiomyocyte cross-sectional areas. *p<0.05; # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 7 to 22 per group; LVEF, LV ejection fraction; LVFS, LV fractional shortening; LVESD, LV end-systolic diameter; LVEDD, LV end-diastolic diameter.
    Female Il 12β Ko, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/female+il+12%CE%B2+ko/12%CE%B2+female+il+knockout/bio_rxiv__2025__09__05__674485-30-2-5
    Average 86 stars, based on 1 article reviews
    female il 12β ko - by Bioz Stars, 2026-09
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) Western blots and quantification of LV IL-12β expression in WT sham and WT TAC mice. (B) Survival curves of WT TAC and IL-12β KO TAC mice of both sexes (log-rank test). (C) Representative M-mode echocardiographic images of WT and IL-12β KO male mice: pre-TAC, 2 weeks, 4 weeks, and 6 weeks after TAC, and Quantified data of echocardiographic measurements of LVEF, LVFS, LVESD, and LVEDD of both sexes. (D, E) The ratio of LV weight, left atrial (LA) weight, lung weight, RV weight, right atrial (RA) weight, and total heart weight to tibial length (TL) of the indicated groups. (F) Representative LV WGA staining images and quantified data of cardiomyocyte cross-sectional areas. *p<0.05; # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 7 to 22 per group; LVEF, LV ejection fraction; LVFS, LV fractional shortening; LVESD, LV end-systolic diameter; LVEDD, LV end-diastolic diameter.

    Journal: bioRxiv

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development

    doi: 10.1101/2025.09.05.674485

    Figure Lengend Snippet: (A) Western blots and quantification of LV IL-12β expression in WT sham and WT TAC mice. (B) Survival curves of WT TAC and IL-12β KO TAC mice of both sexes (log-rank test). (C) Representative M-mode echocardiographic images of WT and IL-12β KO male mice: pre-TAC, 2 weeks, 4 weeks, and 6 weeks after TAC, and Quantified data of echocardiographic measurements of LVEF, LVFS, LVESD, and LVEDD of both sexes. (D, E) The ratio of LV weight, left atrial (LA) weight, lung weight, RV weight, right atrial (RA) weight, and total heart weight to tibial length (TL) of the indicated groups. (F) Representative LV WGA staining images and quantified data of cardiomyocyte cross-sectional areas. *p<0.05; # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 7 to 22 per group; LVEF, LV ejection fraction; LVFS, LV fractional shortening; LVESD, LV end-systolic diameter; LVEDD, LV end-diastolic diameter.

    Article Snippet: Male and female IL-12β KO (Jackson Lab, Strain #002693) and wild-type (WT) C57BL/6J (Jackson Lab, Strain #000664) mice were used for sham or TAC surgery, a commonly used surgical procedure to mimic clinical conditions such as hypertension or aortic stenosis.

    Techniques: Western Blot, Expressing, Staining

    (A) Principal component analysis of WT and IL-12β KO mice, under sham or TAC conditions. (B) Venn diagram showing differentially expressed genes (DEGs) of WT and IL-12β KO mice under sham or TAC conditions, as well as the shared and uniquely changed genes. (C) DEGs cluster heatmap in WT mice compared to IL-12β KO mice, under sham or TAC conditions. (D) Volcano plots showing upregulated and downregulated genes among the groups. (E) Gene ontology (GO) biological process enrichment bubble chart in WT TAC mice compared to IL-12β KO TAC. (F) GO cellular component enrichment histogram shows the enriched cellular components between KO and WT mice after TAC. n = 2/group for sham and n=3/group for TAC.

    Journal: bioRxiv

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development

    doi: 10.1101/2025.09.05.674485

    Figure Lengend Snippet: (A) Principal component analysis of WT and IL-12β KO mice, under sham or TAC conditions. (B) Venn diagram showing differentially expressed genes (DEGs) of WT and IL-12β KO mice under sham or TAC conditions, as well as the shared and uniquely changed genes. (C) DEGs cluster heatmap in WT mice compared to IL-12β KO mice, under sham or TAC conditions. (D) Volcano plots showing upregulated and downregulated genes among the groups. (E) Gene ontology (GO) biological process enrichment bubble chart in WT TAC mice compared to IL-12β KO TAC. (F) GO cellular component enrichment histogram shows the enriched cellular components between KO and WT mice after TAC. n = 2/group for sham and n=3/group for TAC.

    Article Snippet: Male and female IL-12β KO (Jackson Lab, Strain #002693) and wild-type (WT) C57BL/6J (Jackson Lab, Strain #000664) mice were used for sham or TAC surgery, a commonly used surgical procedure to mimic clinical conditions such as hypertension or aortic stenosis.

    Techniques:

    (A) The top 20 upregulated and downregulated pathways between KO and WT mice after TAC, identified by GSEA with ReactomeGSA. (B) Representative GESA plots of collagen formation and extracellular matrix organization. (C, D) Representative images and quantified data of LV interstitial and perivascular fibrosis performed by Sirius Red/Fast Green staining in male and female mice. # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 4-5 per group.

    Journal: bioRxiv

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development

    doi: 10.1101/2025.09.05.674485

    Figure Lengend Snippet: (A) The top 20 upregulated and downregulated pathways between KO and WT mice after TAC, identified by GSEA with ReactomeGSA. (B) Representative GESA plots of collagen formation and extracellular matrix organization. (C, D) Representative images and quantified data of LV interstitial and perivascular fibrosis performed by Sirius Red/Fast Green staining in male and female mice. # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 4-5 per group.

    Article Snippet: Male and female IL-12β KO (Jackson Lab, Strain #002693) and wild-type (WT) C57BL/6J (Jackson Lab, Strain #000664) mice were used for sham or TAC surgery, a commonly used surgical procedure to mimic clinical conditions such as hypertension or aortic stenosis.

    Techniques: Staining

    (A) The top 20 upregulated and downregulated pathways between KO and WT mice after TAC identified by GSEA with KEGG pathway analysis. (B) Heatmap shows the top LV immune and/or inflammation-related genes in KO and WT mice after TAC. (C, D) Representative LV CD45 + immuno-staining images and quantified data of LV CD45 + of the indicated groups. (E) Percentage distribution of major immune cell subsets within LV CD45 + cells of the indicated groups determined by flow cytometry. # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 4-5 per group.

    Journal: bioRxiv

    Article Title: Genetic inhibition of IL-12β suppresses systolic overload-induced cardiac inflammation and heart failure development

    doi: 10.1101/2025.09.05.674485

    Figure Lengend Snippet: (A) The top 20 upregulated and downregulated pathways between KO and WT mice after TAC identified by GSEA with KEGG pathway analysis. (B) Heatmap shows the top LV immune and/or inflammation-related genes in KO and WT mice after TAC. (C, D) Representative LV CD45 + immuno-staining images and quantified data of LV CD45 + of the indicated groups. (E) Percentage distribution of major immune cell subsets within LV CD45 + cells of the indicated groups determined by flow cytometry. # p<0.05 compared to WT sham; † p<0.05 compared to WT TAC; $ p<0.05 compared to IL-12β KO sham; n = 4-5 per group.

    Article Snippet: Male and female IL-12β KO (Jackson Lab, Strain #002693) and wild-type (WT) C57BL/6J (Jackson Lab, Strain #000664) mice were used for sham or TAC surgery, a commonly used surgical procedure to mimic clinical conditions such as hypertension or aortic stenosis.

    Techniques: Immunostaining, Flow Cytometry